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Vulva cancer

MedGen UID:
91196
•Concept ID:
C0375071
•
Neoplastic Process
Synonyms: Cancer of the Vulva; Cancer of Vulva; Cancer, Vulva; Cancer, Vulvar; Cancers, Vulva; Cancers, Vulvar; Vulva Cancer; Vulva Cancers; Vulvar Cancer; Vulvar Cancers
SNOMED CT: Cancer of vulva (363367000); Malignant tumor of vulva (363367000)
 
Monarch Initiative: MONDO:0001528

Definition

A primary or metastatic malignant neoplasm involving the vulva. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVulva cancer

Professional guidelines

PubMed

Sexual and Psychosexual Consequences of Treatment for Gynaecological Cancers.
Rizzuto I, Oehler MK, Lalondrelle S
Clin Oncol (R Coll Radiol) 2021 Sep;33(9):602-607. Epub 2021 Jul 17 doi: 10.1016/j.clon.2021.07.003. PMID: 34281725
Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology.
Zubor P, Wang Y, Liskova A, Samec M, Koklesova L, Dankova Z, Dørum A, Kajo K, Dvorska D, Lucansky V, Malicherova B, Kasubova I, Bujnak J, Mlyncek M, Dussan CA, Kubatka P, Büsselberg D, Golubnitschaja O
Int J Mol Sci 2020 Oct 27;21(21) doi: 10.3390/ijms21217988. PMID: 33121141Free PMC Article
Negative pressure wound treatment (NPWT) in vulva and groin wounds in gynaecologic oncology.
Wahab NAA, Saadeh FA, Wong A, Gleeson N
Eur J Gynaecol Oncol 2016;37(5):632-637. PMID: 29787000

Recent clinical studies

Etiology

TP53 mutation and human papilloma virus status as independent prognostic factors in a Norwegian cohort of vulva squamous cell carcinoma.
Dongre HN, Elnour R, Tornaas S, Fromreide S, Thomsen LCV, Kolseth IBM, Nginamau ES, Johannessen AC, Vintermyr OK, Costea DE, Bjørge L
Acta Obstet Gynecol Scand 2024 Jan;103(1):165-175. Epub 2023 Oct 15 doi: 10.1111/aogs.14689. PMID: 37840151Free PMC Article
Burden of HPV-Related Hospitalization in Germany from 2000 to 2021.
Tampakoudis G, Anastasiou OE
Viruses 2023 Aug 31;15(9) doi: 10.3390/v15091857. PMID: 37766265Free PMC Article
Comorbidity in patients with Lichen sclerosus: a retrospective cohort study.
Gulin SJ, Lundin F, Seifert O
Eur J Med Res 2023 Sep 11;28(1):338. doi: 10.1186/s40001-023-01335-9. PMID: 37697418Free PMC Article
Mapping evidence on ovarian, endometrial, vaginal, and vulva cancer research in Africa: a scoping review protocol.
Ninimiya SY, Ansu-Mensah M, Bawontuo V, Kuupiel D
Syst Rev 2021 Apr 14;10(1):108. doi: 10.1186/s13643-021-01654-0. PMID: 33849664Free PMC Article
Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology.
Zubor P, Wang Y, Liskova A, Samec M, Koklesova L, Dankova Z, Dørum A, Kajo K, Dvorska D, Lucansky V, Malicherova B, Kasubova I, Bujnak J, Mlyncek M, Dussan CA, Kubatka P, Büsselberg D, Golubnitschaja O
Int J Mol Sci 2020 Oct 27;21(21) doi: 10.3390/ijms21217988. PMID: 33121141Free PMC Article

Diagnosis

Comorbidity in patients with Lichen sclerosus: a retrospective cohort study.
Gulin SJ, Lundin F, Seifert O
Eur J Med Res 2023 Sep 11;28(1):338. doi: 10.1186/s40001-023-01335-9. PMID: 37697418Free PMC Article
Sexual and Psychosexual Consequences of Treatment for Gynaecological Cancers.
Rizzuto I, Oehler MK, Lalondrelle S
Clin Oncol (R Coll Radiol) 2021 Sep;33(9):602-607. Epub 2021 Jul 17 doi: 10.1016/j.clon.2021.07.003. PMID: 34281725
Mapping evidence on ovarian, endometrial, vaginal, and vulva cancer research in Africa: a scoping review protocol.
Ninimiya SY, Ansu-Mensah M, Bawontuo V, Kuupiel D
Syst Rev 2021 Apr 14;10(1):108. doi: 10.1186/s13643-021-01654-0. PMID: 33849664Free PMC Article
Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology.
Zubor P, Wang Y, Liskova A, Samec M, Koklesova L, Dankova Z, Dørum A, Kajo K, Dvorska D, Lucansky V, Malicherova B, Kasubova I, Bujnak J, Mlyncek M, Dussan CA, Kubatka P, Büsselberg D, Golubnitschaja O
Int J Mol Sci 2020 Oct 27;21(21) doi: 10.3390/ijms21217988. PMID: 33121141Free PMC Article
Development of target-specific multimodality imaging agent by using hollow manganese oxide nanoparticles as a platform.
Ha TL, Kim HJ, Shin J, Im GH, Lee JW, Heo H, Yang J, Kang CM, Choe YS, Lee JH, Lee IS
Chem Commun (Camb) 2011 Aug 28;47(32):9176-8. Epub 2011 Jul 15 doi: 10.1039/c1cc12961a. PMID: 21761053

Therapy

Association between radiation therapy for primary endometrial cancer and risk of second primary malignancies: a retrospective cohort study.
Wang Y, Cai Y
Sci Rep 2024 Oct 19;14(1):24623. doi: 10.1038/s41598-024-74840-4. PMID: 39427001Free PMC Article
Immunotherapy and radiation therapy sequencing: State of the data on timing, efficacy, and safety.
Williamson CW, Sherer MV, Zamarin D, Sharabi AB, Dyer BA, Mell LK, Mayadev JS
Cancer 2021 May 15;127(10):1553-1567. Epub 2021 Feb 23 doi: 10.1002/cncr.33424. PMID: 33620731Free PMC Article
Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology.
Zubor P, Wang Y, Liskova A, Samec M, Koklesova L, Dankova Z, Dørum A, Kajo K, Dvorska D, Lucansky V, Malicherova B, Kasubova I, Bujnak J, Mlyncek M, Dussan CA, Kubatka P, Büsselberg D, Golubnitschaja O
Int J Mol Sci 2020 Oct 27;21(21) doi: 10.3390/ijms21217988. PMID: 33121141Free PMC Article
A review of complications associated with the surgical treatment of vulvar cancer.
Wills A, Obermair A
Gynecol Oncol 2013 Nov;131(2):467-79. Epub 2013 Jul 14 doi: 10.1016/j.ygyno.2013.07.082. PMID: 23863358
Chemotherapy and radiation therapy in the treatment of squamous cell carcinoma of the vulva: Are two therapies better than one?
Moore DH
Gynecol Oncol 2009 Jun;113(3):379-83. Epub 2009 Feb 20 doi: 10.1016/j.ygyno.2009.01.004. PMID: 19232700

Prognosis

Association between radiation therapy for primary endometrial cancer and risk of second primary malignancies: a retrospective cohort study.
Wang Y, Cai Y
Sci Rep 2024 Oct 19;14(1):24623. doi: 10.1038/s41598-024-74840-4. PMID: 39427001Free PMC Article
TP53 mutation and human papilloma virus status as independent prognostic factors in a Norwegian cohort of vulva squamous cell carcinoma.
Dongre HN, Elnour R, Tornaas S, Fromreide S, Thomsen LCV, Kolseth IBM, Nginamau ES, Johannessen AC, Vintermyr OK, Costea DE, Bjørge L
Acta Obstet Gynecol Scand 2024 Jan;103(1):165-175. Epub 2023 Oct 15 doi: 10.1111/aogs.14689. PMID: 37840151Free PMC Article
Temporal Trends and Projection of Cancer Attributable to Human Papillomavirus Infection in China, 2007-2030.
Duan R, Xu K, Huang L, Yuan M, Wang H, Qiao Y, Zhao F
Cancer Epidemiol Biomarkers Prev 2022 May 4;31(5):1130-1136. doi: 10.1158/1055-9965.EPI-21-1124. PMID: 35266990
Sexual and Psychosexual Consequences of Treatment for Gynaecological Cancers.
Rizzuto I, Oehler MK, Lalondrelle S
Clin Oncol (R Coll Radiol) 2021 Sep;33(9):602-607. Epub 2021 Jul 17 doi: 10.1016/j.clon.2021.07.003. PMID: 34281725
Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology.
Zubor P, Wang Y, Liskova A, Samec M, Koklesova L, Dankova Z, Dørum A, Kajo K, Dvorska D, Lucansky V, Malicherova B, Kasubova I, Bujnak J, Mlyncek M, Dussan CA, Kubatka P, Büsselberg D, Golubnitschaja O
Int J Mol Sci 2020 Oct 27;21(21) doi: 10.3390/ijms21217988. PMID: 33121141Free PMC Article

Clinical prediction guides

Association between radiation therapy for primary endometrial cancer and risk of second primary malignancies: a retrospective cohort study.
Wang Y, Cai Y
Sci Rep 2024 Oct 19;14(1):24623. doi: 10.1038/s41598-024-74840-4. PMID: 39427001Free PMC Article
TP53 mutation and human papilloma virus status as independent prognostic factors in a Norwegian cohort of vulva squamous cell carcinoma.
Dongre HN, Elnour R, Tornaas S, Fromreide S, Thomsen LCV, Kolseth IBM, Nginamau ES, Johannessen AC, Vintermyr OK, Costea DE, Bjørge L
Acta Obstet Gynecol Scand 2024 Jan;103(1):165-175. Epub 2023 Oct 15 doi: 10.1111/aogs.14689. PMID: 37840151Free PMC Article
Burden of HPV-Related Hospitalization in Germany from 2000 to 2021.
Tampakoudis G, Anastasiou OE
Viruses 2023 Aug 31;15(9) doi: 10.3390/v15091857. PMID: 37766265Free PMC Article
Financial toxicity in patients with gynecologic malignancies: a cross sectional study.
Zeybek B, Webster E, Pogosian N, Tymon-Rosario J, Balch A, Altwerger G, Clark M, Menderes G, Huang G, Azodi M, Ratner ES, Schwartz PE, Santin AD, Andikyan V
J Gynecol Oncol 2021 Nov;32(6):e87. Epub 2021 Jul 23 doi: 10.3802/jgo.2021.32.e87. PMID: 34431257Free PMC Article
Cold Atmospheric Pressure Plasma (CAP) as a New Tool for the Management of Vulva Cancer and Vulvar Premalignant Lesions in Gynaecological Oncology.
Zubor P, Wang Y, Liskova A, Samec M, Koklesova L, Dankova Z, Dørum A, Kajo K, Dvorska D, Lucansky V, Malicherova B, Kasubova I, Bujnak J, Mlyncek M, Dussan CA, Kubatka P, Büsselberg D, Golubnitschaja O
Int J Mol Sci 2020 Oct 27;21(21) doi: 10.3390/ijms21217988. PMID: 33121141Free PMC Article

Recent systematic reviews

Assessing Patient-reported Quality of Life Outcomes in Vulva Cancer Patients: A Systematic Literature Review.
Froeding LP, Greimel E, Lanceley A, Oberguggenberger A, Schmalz C, Radisic VB, Nordin A, Galalaei R, Kuljanic K, Vistad I, Schnack TH, Jensen PT; European Organization of Research Treatment of Cancer Quality of Life Group the Gynecological Cancer group
Int J Gynecol Cancer 2018 May;28(4):808-817. doi: 10.1097/IGC.0000000000001211. PMID: 29420364
Locally advanced vulva cancer: A single centre review of anovulvectomy and a systematic review of surgical, chemotherapy and radiotherapy alternatives. Is an international collaborative RCT destined for the "too difficult to do" box?
O'Donnell RL, Verleye L, Ratnavelu N, Galaal K, Fisher A, Naik R
Gynecol Oncol 2017 Feb;144(2):438-447. Epub 2016 Dec 27 doi: 10.1016/j.ygyno.2016.12.007. PMID: 28034465

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