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Series GSE2672 Query DataSets for GSE2672
Status Public on Jun 29, 2005
Title A high-resolution map of active promoters in the human genome
Organism Homo sapiens
Experiment type Expression profiling by array
Genome binding/occupancy profiling by genome tiling array
Summary Our ability to understand the control logic embedded in the human genome is limited by a lack of accurate information of the promoter sequences for most genes. Promoters are a unique class of control sequences, serving as the binding sites for both sequence-specific factors and the general transcription machinery during transcription initiation. In order to obtain a comprehensive map of promoters in the human genome, we have determined the location of the RNA polymerase II preinitiation complex throughout the non-repeat sequences of the human genome in primary fibroblast cells. The resulting map defines 10,571 active promoters corresponding to 6,763 known genes and at least 1,199 un-annotated transcriptional units. The map indicates extensive usage of multiple promoters by the human genes and widespread clustering of active promoters in the genome. Further examination of the genome-wide expression profile reveals four general classes of promoters that define the transcriptome of the cell. Our results provide a global view of the functional relationship among the transcriptional machinery, chromatin structure, and gene expression in human cells.
Keywords = GALA
Keywords = gene expression
Keywords = nimblegen
Keywords = promoter profile
Keywords = LICR renlab
Keywords: other
 
Web link http://licr-renlab.ucsd.edu
 
Contributor(s) Kim T, Barrera LO, Zheng M, Qu C, Singer MA, Richmond TA, Wu Y, Green RD, Ren B
Citation(s) 15988478, 17571346
Submission date May 17, 2005
Last update date Mar 25, 2019
Contact name Chunxu Qu
E-mail(s) [email protected]
Phone (858)822-5767
Organization name Ludwig Institute for Cancer Research
Department Gene Regulation
Lab RenLab
Street address
City San Diego
State/province CA
ZIP/Postal code 92093
Country USA
 
Platforms (41)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
GPL2052 Human tiling array using Nimblegen platform, set 1 of 38
GPL2053 Human tiling array using Nimblegen platform, set 2 of 38
Samples (49)
GSM51626 gene express in IMR90 cells, biological replicate 1 of 2
GSM51627 gene express in IMR90 cells, biological replicate 2 of 2
GSM51734 genome scan: TAF1-IMR90 set 35 of 38
Relations
BioProject PRJNA92111

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