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Nongerminomatous germ cell tumor

MedGen UID:
220426
•Concept ID:
C1266158
•
Neoplastic Process
Synonyms: Germ cell tumor, nonseminomatous; Non-seminomatous germ-cell tumors; NONSEMINOMATOUS GERM CELL TUMORS, SOMATIC
SNOMED CT: Germ cell tumor, nonseminomatous (128766005)
 
Monarch Initiative: MONDO:0021656
OMIM®: 273300

Definition

A term that refers to teratoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, or mixed forms of these tumors. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNongerminomatous germ cell tumor

Professional guidelines

PubMed

Longitudinal evaluation of neurocognitive function after treatment for central nervous system germ cell tumors in childhood.
Mabbott DJ, Monsalves E, Spiegler BJ, Bartels U, Janzen L, Guger S, Laperriere N, Andrews N, Bouffet E
Cancer 2011 Dec 1;117(23):5402-11. Epub 2011 May 11 doi: 10.1002/cncr.26127. PMID: 21563173
Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Testicular Cancer, 2024

Recent clinical studies

Etiology

Split-Tendon Medial Transposition of Lateral Rectus for Pediatric Complete Oculomotor Palsy.
Zhang KX, Varma H, Cao Y, Shah VS
J Neuroophthalmol 2023 Jun 1;43(2):254-260. Epub 2022 Nov 7 doi: 10.1097/WNO.0000000000001731. PMID: 36342135Free PMC Article
Feasibility of treating pediatric intracranial germ cell tumors in a middle-income country: The Jordanian experience.
Amayiri N, Sarhan N, Yousef Y, Ibrahimi AK, Abu-Shanab S, Al-Zebin Z, Al-Hussaini M, Musharbash A, Tawalbeh A, Bouffet E, Bartels U
Pediatr Blood Cancer 2022 Dec;69(12):e30011. Epub 2022 Sep 21 doi: 10.1002/pbc.30011. PMID: 36131594
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Atypical location and clinical behavior of a subset of intracranial germ cell tumors in children younger than 3 years of age.
Teo WY, Ross J, Bollo RJ, Seow WT, Tan AM, Kang SG, Kim DS, Li XN, Lau CC, Mohila CA, Adesina AM, Su JM
J Neurosurg Pediatr 2014 Oct;14(4):348-55. Epub 2014 Jul 25 doi: 10.3171/2014.6.PEDS13651. PMID: 25062305
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765

Diagnosis

Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Central Nervous System Germ Cell Tumors: A Review of the Literature.
Kong Z, Wang Y, Dai C, Yao Y, Ma W, Wang Y
J Child Neurol 2018 Aug;33(9):610-620. Epub 2018 May 30 doi: 10.1177/0883073818772470. PMID: 29848146
Atypical location and clinical behavior of a subset of intracranial germ cell tumors in children younger than 3 years of age.
Teo WY, Ross J, Bollo RJ, Seow WT, Tan AM, Kang SG, Kim DS, Li XN, Lau CC, Mohila CA, Adesina AM, Su JM
J Neurosurg Pediatr 2014 Oct;14(4):348-55. Epub 2014 Jul 25 doi: 10.3171/2014.6.PEDS13651. PMID: 25062305
Extraneural metastasis of a nongerminomatous germ cell tumor of the central nervous system in a pediatric patient with a ventriculoperitoneal shunt: a case report and review of the literature.
Belongia M, Jogal S
J Pediatr Hematol Oncol 2012 Jan;34(1):e12-6. doi: 10.1097/MPH.0b013e31823dd370. PMID: 22215101
Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview.
Fujimaki T
J Child Neurol 2009 Nov;24(11):1439-45. doi: 10.1177/0883073809342127. PMID: 19841431

Therapy

Off-label prescribing of immune checkpoint inhibitor therapy at a single pediatric cancer center.
Gikandi A, Chi SN, Yeo KK, O'Neill AF, Shulman DS, DuBois SG, Collins NB
Cancer Med 2024 Apr;13(8):e7154. doi: 10.1002/cam4.7154. PMID: 38629258Free PMC Article
Feasibility of treating pediatric intracranial germ cell tumors in a middle-income country: The Jordanian experience.
Amayiri N, Sarhan N, Yousef Y, Ibrahimi AK, Abu-Shanab S, Al-Zebin Z, Al-Hussaini M, Musharbash A, Tawalbeh A, Bouffet E, Bartels U
Pediatr Blood Cancer 2022 Dec;69(12):e30011. Epub 2022 Sep 21 doi: 10.1002/pbc.30011. PMID: 36131594
A phase I study of sirolimus in combination with metronomic therapy (CHOAnome) in children with recurrent or refractory solid and brain tumors.
Qayed M, Cash T, Tighiouart M, MacDonald TJ, Goldsmith KC, Tanos R, Kean L, Watkins B, Suessmuth Y, Wetmore C, Katzenstein HM
Pediatr Blood Cancer 2020 Apr;67(4):e28134. Epub 2019 Dec 25 doi: 10.1002/pbc.28134. PMID: 31876107
Ophthalmological outcomes of patients treated for pineal region tumors.
Hankinson EV, Lyons CJ, Hukin J, Cochrane DD
J Neurosurg Pediatr 2016 May;17(5):558-63. Epub 2016 Jan 22 doi: 10.3171/2015.10.PEDS15415. PMID: 26799411
The growing teratoma syndrome in a nongerminomatous germ cell tumor of the pineal gland: a case report and review.
O'Callaghan AM, Katapodis O, Ellison DW, Theaker JM, Mead GM
Cancer 1997 Sep 1;80(5):942-7. doi: 10.1002/(sici)1097-0142(19970901)80:5<942::aid-cncr16>3.0.co;2-w. PMID: 9307195

Prognosis

Apparent diffusion coefficient of intracranial germ cell tumors.
Ogiwara H, Tsutsumi Y, Matsuoka K, Kiyotani C, Terashima K, Morota N
J Neurooncol 2015 Feb;121(3):565-71. Epub 2014 Nov 21 doi: 10.1007/s11060-014-1668-y. PMID: 25413617
Atypical location and clinical behavior of a subset of intracranial germ cell tumors in children younger than 3 years of age.
Teo WY, Ross J, Bollo RJ, Seow WT, Tan AM, Kang SG, Kim DS, Li XN, Lau CC, Mohila CA, Adesina AM, Su JM
J Neurosurg Pediatr 2014 Oct;14(4):348-55. Epub 2014 Jul 25 doi: 10.3171/2014.6.PEDS13651. PMID: 25062305
Treatment of intracranial nongerminomatous germ-cell tumor by high-dose chemotherapy and autologous stem-cell rescue.
Tada T, Takizawa T, Nakazato F, Kobayashi S, Koike K, Oguchi M, Ishii E, Amano Y
J Neurooncol 1999 Aug;44(1):71-6. doi: 10.1023/a:1006395719917. PMID: 10582672
Germ cell tumors of the CNS in children: recent advances in therapy.
Diez B, Balmaceda C, Matsutani M, Weiner HL
Childs Nerv Syst 1999 Oct;15(10):578-85. doi: 10.1007/s003810050546. PMID: 10550589
Treatment of nongerminomatous germ-cell tumors of the pineal region.
Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ
Neurosurgery 1994 Mar;34(3):524-9; discussion 529. doi: 10.1227/00006123-199403000-00021. PMID: 7514765

Clinical prediction guides

Split-Tendon Medial Transposition of Lateral Rectus for Pediatric Complete Oculomotor Palsy.
Zhang KX, Varma H, Cao Y, Shah VS
J Neuroophthalmol 2023 Jun 1;43(2):254-260. Epub 2022 Nov 7 doi: 10.1097/WNO.0000000000001731. PMID: 36342135Free PMC Article
Primary intracranial pure endodermal sinus tumor: A retrospective series of 6 cases in a single center and a systematic review of overall survival.
Raynald, Yang H, Zhang X, Ma'ruf L, Li C, Jiang T
Neurochirurgie 2021 Nov;67(6):587-598. Epub 2021 Mar 19 doi: 10.1016/j.neuchi.2021.02.014. PMID: 33753128
Primary and Recurrent Growing Teratoma Syndrome in Central Nervous System Nongerminomatous Germ Cell Tumors: Case Series and Review of the Literature.
Tsuyuguchi S, Sugiyama K, Kinoshita Y, Kolakshyapati M, Takayasu T, Usui S, Takano M, Yonezawa U, Taguchi A, Amatya VJ, Takeshima Y, Kurisu K, Yamasaki F
World Neurosurg 2020 Feb;134:e360-e371. Epub 2019 Nov 18 doi: 10.1016/j.wneu.2019.10.074. PMID: 31751614
Clinical features, radiologic findings, and treatment of pediatric germ cell tumors involving the basal ganglia and thalamus: a retrospective series of 15 cases at a single center.
Wang M, Zhou P, Zhang S, Liu X, Lv L, Wang Z, Ye F, Ju Y, Jiang S
Childs Nerv Syst 2018 Mar;34(3):423-430. Epub 2017 Oct 24 doi: 10.1007/s00381-017-3632-6. PMID: 29067503
Apparent diffusion coefficient of intracranial germ cell tumors.
Ogiwara H, Tsutsumi Y, Matsuoka K, Kiyotani C, Terashima K, Morota N
J Neurooncol 2015 Feb;121(3):565-71. Epub 2014 Nov 21 doi: 10.1007/s11060-014-1668-y. PMID: 25413617

Recent systematic reviews

Primary intracranial pure endodermal sinus tumor: A retrospective series of 6 cases in a single center and a systematic review of overall survival.
Raynald, Yang H, Zhang X, Ma'ruf L, Li C, Jiang T
Neurochirurgie 2021 Nov;67(6):587-598. Epub 2021 Mar 19 doi: 10.1016/j.neuchi.2021.02.014. PMID: 33753128

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Testicular Cancer, 2024

    Reviews

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