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Status
Public on Apr 01, 2005
Title
chemotherapy cross-resistance and treatment response in childhood acute lymphoblastic leukemia
Organism
Homo sapiens Experiment type
Expression profiling by array
Summary
Acute lymphoblastic leukemia (ALL) can be cured with combination chemotherapy in over 75% of children, but the cause of treatment failure in the remaining patients is unknown. We determined the sensitivity of ALL cells to individual antileukemic agents in 441 patients, and used a genome-wide approach to identify 45 genes differentially expressed in ALL exhibiting cross-resistance to prednisolone, vincristine, asparaginase and daunorubicin. We also identified a distinct phenotype of discordant resistance to asparaginase and vincristine and 139 genes whose expression was associated with this novel phenotype. The expression of these genes discriminated treatment outcome in two independent patient populations, identifying a subset of patients with a markedly inferior outcome (37%±13% 5-year DFS).
Contributor(s)
Lugthart S , Cheok MH , den Boer ML , Yang W , Holleman A , Cheng C , Pui C , Relling MV , Janka-Schaub GE , Pieters R , Evans WE Citation(s)
15837626 Submission date
Feb 28, 2005
Last update date
Aug 10, 2018
Contact name
William E Evans
E-mail(s)
[email protected] Phone
901-495-4995
Fax
901-495-6869
URL
http://www.stjude.org/leukemia/bio_evans.htm Organization name
St.Jude Children's Research Hospital
Department
Pharmaceutical Sciences
Lab
Evans
Street address
332 N. Lauderdale St.
City
Memphis
State/province
TN
ZIP/Postal code
38105
Country
USA
Platforms (1)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
Samples (129)
Relations BioProject
PRJNA91647
Drug resistance to Asparaginase (ASP), daunorubicin (DNR), prednisolone (PRD), vincristine (VCR) and cross resistance component 1, 2, 3 header descriptions code gsm LC50 ASP LC50 DNR LC50 PRED LC50 VCR Comp1 Comp2 Comp3
Data table code gsm LC50 ASP LC50 DNR LC50 PRED LC50 VCR Comp1 Comp2 Comp3 nl001
GSM9653
0.0617
0.1985
250
0.6859
-1.672435753
-0.139430681
1.307921513
nl002
GSM9654
0.0107
0.0682
0.1322
1.7681
0.127148204
-1.218095436
-0.176316251
nl003
GSM9655
0.0032
0.0297
0.0595
0.0488
1.821063185
-0.030519277
0.871639564
nl004
GSM9656
0.0032
0.029
0.1055
0.1784
1.403401501
-0.548250001
0.640279607
nl005
GSM9657
0.0032
0.0236
0.315
0.1575
1.369460896
-0.441178276
0.89914253
nl006
GSM9658
0.0032
0.002
0.0076
0.0488
3.572087613
0.110644915
0.380361111
nl012
GSM9694
0.0032
0.011
0.0599
0.458
1.758554458
-0.884099486
0.244805939
nl013
GSM9695
0.88
0.0461
0.0571
0.5078
0.097874319
0.564658752
-0.978803894
nl014
GSM9696
0.0147
0.0597
0.2889
0.2668
0.515998286
-0.301183514
0.428242103
nl016
GSM9698
0.0373
0.075
0.2829
0.089
0.538940833
0.403693504
0.524413515
nl017
GSM9699
0.0032
0.019
0.3183
0.0488
1.788064182
0.064448768
1.213896846
nl019
GSM9701
0.0747
0.0149
0.3545
0.0488
1.401796994
0.989014469
0.548536274
nl020
GSM9702
0.0032
0.0283
0.049
39.836
0.126405959
-2.826322087
-0.986032924
nl021
GSM9703
0.0032
0.089
2.054
0.3868
0.135266107
-0.85426862
1.078591741
nl022
GSM9704
0.0063
0.0231
0.038
0.162
1.604975409
-0.332425267
0.300243832
nl023
GSM9707
0.0093
0.0178
0.1522
1.3417
0.906621605
-1.031639018
-0.07111935
nl024
GSM9708
0.0032
0.0076
0.1465
1.5698
1.48852591
-1.336108177
0.090825814
nl025
GSM9709
0.0144
0.0104
1.0827
0.6747
0.986348511
-0.507920509
0.420414102
nl026
GSM9710
0.0032
0.0757
0.41225
0.64603
0.343455789
-1.112077239
0.598981807
nl027
GSM9711
2
0.075
195.3125
0.2015
-1.349041742
1.434685655
0.812696467
129 9 Kbytes .Supplementary file Size Download File type/resource GSE2351_RAW.tar
389.8 Mb
(http) (custom) TAR (of CEL)
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