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| Status |
Public on Jun 07, 2006 |
| Title |
A Biologic Definition of Burkitt's Lymphoma from Transcriptional and Genomic Profiling |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The distinction between the Burkitt lymphoma and diffuse large B-cell lymphoma is imprecise using current diagnostic criteria. We applied transcriptional and genomic profiling to molecularly define Burkitt lymphoma. Gene expression profiling employing Affymetrix GeneChips (U133A) was performed in 220 mature aggressive B-cell lymphomas, including a core group of eight Burkitt lymphomas, which fulfilled all diagnostic criteria of the WHO classification. A molecular signature of Burkitt lymphoma was generated. Chromosomal abnormalities were detected by interphase fluorescence in-situ hybridization and array comparative genomic hybridization. The molecular Burkitt lymphoma signature identified 44 cases. Fifteen of these cases lacked a morphology typical for Burkitt/Burkitt-like lymphoma. The vast majority (88%) of the 176 lymphomas without the molecular Burkitt lymphoma signature represented diffuse large B-cell lymphomas. In 20% of these cases a MYC break was detectable which was associated with complex chromosomal changes. Our molecular definition of Burkitt lymphoma sharpens and extends the spectrum of Burkitt lymphoma. In mature aggressive B-cell lymphomas without a Burkitt lymphoma signature, a chromosomal break in the MYC locus proved to be associated with adverse clinical outcome.
Keywords: Gene expression
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| Overall design |
220 diffuse large B-cell lymphoma and Burkitt lymphoma samples hybridized to 221 HGU133A Affymetrix GeneChips
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| Web link |
http://compdiag.molgen.mpg.de/supplements/Hummel06
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| Contributor(s) |
Hummel M, Bentink S, Berger H, Klapper W, Wessendorf S, Barth TF, Bernd H, Cogliatti S, Dierlamm J, Feller AC, Hansmann M, Haralambieva E, Harder L, Hasenclever D, Kuehn M, Lenze D, Lichter P, Martin-Subero JI, Moeller P, Mueller-Hermelink H, Ott G, Parwaresch RM, Pott C, Rosenwald A, Rosolowski M, Schwaenen C, Stuerzenhofecker B, Szczepanowski M, Trautmann H, Wacker H, Spang R, Loeffler M, Truemper L, Stein H, Siebert R |
| Citation(s) |
16760442, 23143595 |
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| Submission date |
Mar 15, 2006 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Michael Hummel |
| Organization name |
Universitätsmedizin Berlin, Campus Benjamin Franklin
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| Department |
Institute of Pathology
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| Street address |
Hindenburgdamm 30
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| City |
Berlin |
| ZIP/Postal code |
12200 |
| Country |
Germany |
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| Platforms (1) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
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| Samples (221)
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| Relations |
| BioProject |
PRJNA94549 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE4475_Clinical.csv |
50.0 Kb |
(ftp)(http) |
CSV |
| GSE4475_RAW.tar |
767.0 Mb |
(http)(custom) |
TAR (of CEL) |
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