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Neuroendocrine neoplasm

MedGen UID:
64652
Concept ID:
C0206754
Neoplastic Process
Synonyms: Neuroendocrine Tumor; Neuroendocrine Tumors; Tumor, Neuroendocrine; Tumors, Neuroendocrine
SNOMED CT: Neuroendocrine neoplasm (128928004); Well-differentiated neuroendocrine tumor (1286768001); Neuroendocrine tumor (1288045008); Well-differentiated neuroendocrine tumor (1288045008); NEN - neuroendocrine neoplasm (1290052006); Neuroendocrine neoplasm (1290052006)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
Concept ID:
CN307042
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
 
HPO: HP:0100634
Monarch Initiative: MONDO:0019496
Orphanet: ORPHA877

Definition

A tumor that originates from a neuroendocrine cell. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeuroendocrine neoplasm

Professional guidelines

PubMed

Rossi RE, Elvevi A, Citterio D, Coppa J, Invernizzi P, Mazzaferro V, Massironi S
World J Gastroenterol 2021 Sep 21;27(35):5890-5907. doi: 10.3748/wjg.v27.i35.5890. PMID: 34629807Free PMC Article
Ito T, Masui T, Komoto I, Doi R, Osamura RY, Sakurai A, Ikeda M, Takano K, Igarashi H, Shimatsu A, Nakamura K, Nakamoto Y, Hijioka S, Morita K, Ishikawa Y, Ohike N, Kasajima A, Kushima R, Kojima M, Sasano H, Hirano S, Mizuno N, Aoki T, Aoki T, Ohtsuka T, Okumura T, Kimura Y, Kudo A, Konishi T, Matsumoto I, Kobayashi N, Fujimori N, Honma Y, Morizane C, Uchino S, Horiuchi K, Yamasaki M, Matsubayashi J, Sato Y, Sekiguchi M, Abe S, Okusaka T, Kida M, Kimura W, Tanaka M, Majima Y, Jensen RT, Hirata K, Imamura M, Uemoto S
J Gastroenterol 2021 Nov;56(11):1033-1044. Epub 2021 Sep 29 doi: 10.1007/s00535-021-01827-7. PMID: 34586495Free PMC Article
Kawasaki K, Toshimitsu K, Matano M, Fujita M, Fujii M, Togasaki K, Ebisudani T, Shimokawa M, Takano A, Takahashi S, Ohta Y, Nanki K, Igarashi R, Ishimaru K, Ishida H, Sukawa Y, Sugimoto S, Saito Y, Maejima K, Sasagawa S, Lee H, Kim HG, Ha K, Hamamoto J, Fukunaga K, Maekawa A, Tanabe M, Ishihara S, Hamamoto Y, Yasuda H, Sekine S, Kudo A, Kitagawa Y, Kanai T, Nakagawa H, Sato T
Cell 2020 Nov 25;183(5):1420-1435.e21. Epub 2020 Nov 6 doi: 10.1016/j.cell.2020.10.023. PMID: 33159857

Recent clinical studies

Etiology

Vocino Trucco G, Righi L, Volante M, Papotti M
Histopathology 2024 Jan;84(1):67-85. Epub 2023 Oct 4 doi: 10.1111/his.15058. PMID: 37794655
Andrini E, Lamberti G, Alberici L, Ricci C, Campana D
Curr Treat Options Oncol 2023 Jul;24(7):742-756. Epub 2023 May 4 doi: 10.1007/s11864-023-01093-0. PMID: 37140773Free PMC Article
Brown IS, Sokolova A, Rosty C, Graham RP
Histopathology 2023 Jan;82(2):232-241. Epub 2022 Aug 24 doi: 10.1111/his.14769. PMID: 35962741
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592

Diagnosis

Sakellis C, Jacene HA
PET Clin 2024 Jul;19(3):325-339. Epub 2024 May 6 doi: 10.1016/j.cpet.2024.03.008. PMID: 38714399
Asa SL, Mete O, Perry A, Osamura RY
Endocr Pathol 2022 Mar;33(1):6-26. Epub 2022 Mar 15 doi: 10.1007/s12022-022-09703-7. PMID: 35291028
Nicholson AG, Tsao MS, Beasley MB, Borczuk AC, Brambilla E, Cooper WA, Dacic S, Jain D, Kerr KM, Lantuejoul S, Noguchi M, Papotti M, Rekhtman N, Scagliotti G, van Schil P, Sholl L, Yatabe Y, Yoshida A, Travis WD
J Thorac Oncol 2022 Mar;17(3):362-387. Epub 2021 Nov 20 doi: 10.1016/j.jtho.2021.11.003. PMID: 34808341
Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914Free PMC Article
Jensen RT, Bodei L, Capdevila J, Couvelard A, Falconi M, Glasberg S, Kloppel G, Lamberts S, Peeters M, Rindi G, Rinke A, Rothmund M, Sundin A, Welin S, Fazio N; The ENETS 2016 Munich Advisory Board Participants; ENETS 2016 Munich Advisory Board Participants
Neuroendocrinology 2019;108(1):26-36. Epub 2018 Oct 3 doi: 10.1159/000494258. PMID: 30282083

Therapy

Fodil-Cherif S, Desailloud R, Brue T
Ann Endocrinol (Paris) 2023 Apr;84(2):291-297. Epub 2023 Jan 20 doi: 10.1016/j.ando.2022.12.424. PMID: 36690074
Di Molfetta S, Dotto A, Fanciulli G, Florio T, Feola T, Colao A, Faggiano A
Front Endocrinol (Lausanne) 2021;12:667784. Epub 2021 Apr 14 doi: 10.3389/fendo.2021.667784. PMID: 33935977Free PMC Article
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Sonbol MB, Halfdanarson TR
Curr Treat Options Oncol 2019 Aug 19;20(9):74. doi: 10.1007/s11864-019-0670-1. PMID: 31428952
Ramahi E, Choi J, Fuller CD, Eng TY
Am J Clin Oncol 2013 Jun;36(3):299-309. doi: 10.1097/COC.0b013e318210f83c. PMID: 21422993Free PMC Article

Prognosis

Nicholson AG, Tsao MS, Beasley MB, Borczuk AC, Brambilla E, Cooper WA, Dacic S, Jain D, Kerr KM, Lantuejoul S, Noguchi M, Papotti M, Rekhtman N, Scagliotti G, van Schil P, Sholl L, Yatabe Y, Yoshida A, Travis WD
J Thorac Oncol 2022 Mar;17(3):362-387. Epub 2021 Nov 20 doi: 10.1016/j.jtho.2021.11.003. PMID: 34808341
Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914Free PMC Article
Van de Moortele M, De Hertogh G, Sagaert X, Van Cutsem E
Acta Gastroenterol Belg 2020 Jul-Sep;83(3):441-448. PMID: 33094592
Clift AK, Kidd M, Bodei L, Toumpanakis C, Baum RP, Oberg K, Modlin IM, Frilling A
Neuroendocrinology 2020;110(6):444-476. Epub 2019 Sep 27 doi: 10.1159/000503721. PMID: 31557758Free PMC Article
Jensen RT, Bodei L, Capdevila J, Couvelard A, Falconi M, Glasberg S, Kloppel G, Lamberts S, Peeters M, Rindi G, Rinke A, Rothmund M, Sundin A, Welin S, Fazio N; The ENETS 2016 Munich Advisory Board Participants; ENETS 2016 Munich Advisory Board Participants
Neuroendocrinology 2019;108(1):26-36. Epub 2018 Oct 3 doi: 10.1159/000494258. PMID: 30282083

Clinical prediction guides

Ye M, Lu F, Gu D, Xue B, Xu L, Hu C, Chen J, Yu P, Zheng H, Gao Y, Wang J, Tang Q
FASEB J 2024 Jul 15;38(13):e23762. doi: 10.1096/fj.202302489RRR. PMID: 38923643
Krieg S, Roderburg C, Fung S, Luedde T, Knoefel WT, Krieg A
J Cancer Res Clin Oncol 2022 Sep;148(9):2235-2246. Epub 2022 Apr 15 doi: 10.1007/s00432-022-04013-1. PMID: 35428913Free PMC Article
Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914Free PMC Article
Clift AK, Kidd M, Bodei L, Toumpanakis C, Baum RP, Oberg K, Modlin IM, Frilling A
Neuroendocrinology 2020;110(6):444-476. Epub 2019 Sep 27 doi: 10.1159/000503721. PMID: 31557758Free PMC Article
Pak LM, Yang T, Wang J
J Gastrointest Surg 2019 Apr;23(4):720-729. Epub 2018 Jun 27 doi: 10.1007/s11605-018-3845-3. PMID: 29951901

Recent systematic reviews

Paisey SA, Weerasuriya S, Palmer K, White BE, Srirajaskanthan R, Chandrakumaran K, Ramage JK
J Neuroendocrinol 2022 Dec;34(12):e13215. Epub 2022 Dec 16 doi: 10.1111/jne.13215. PMID: 36524462
Schuch LF, Schmidt TR, de Oliveira Zigmundo G, Kirschnick LB, Silveira FM, Martins MAT, Carlos R, Dos Santos JN, Fonseca FP, Vargas PA, Wagner VP, Martins MD
Head Neck Pathol 2022 Jun;16(2):525-537. Epub 2021 Dec 6 doi: 10.1007/s12105-021-01398-2. PMID: 34870796Free PMC Article
Han S, Lee HS, Woo S, Kim TH, Yoo C, Ryoo BY, Ryu JS
Clin Nucl Med 2021 Sep 1;46(9):723-731. doi: 10.1097/RLU.0000000000003682. PMID: 34028406
Wu Y, Xiong G, Zhang H, Wang M, Zhu F, Qin R
Endocr Pract 2021 Feb;27(2):152-157. Epub 2021 Feb 3 doi: 10.1016/j.eprac.2020.10.012. PMID: 33616046
Figiel JH, Viniol SG, Görlach J, Rinke A, Librizzi D, Mahnken AH
Rofo 2020 Feb;192(2):171-182. Epub 2019 Sep 11 doi: 10.1055/a-1001-2412. PMID: 31509861

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